Index: firmware/App/HDCommon.h
===================================================================
diff -u -reeeb0e3bd5139142394b4b454dcc5b5583cd2e29 -r9fc107ffe0ed515acf970426ff467abd8e7247a8
--- firmware/App/HDCommon.h	(.../HDCommon.h)	(revision eeeb0e3bd5139142394b4b454dcc5b5583cd2e29)
+++ firmware/App/HDCommon.h	(.../HDCommon.h)	(revision 9fc107ffe0ed515acf970426ff467abd8e7247a8)
@@ -84,6 +84,7 @@
     #define SKIP_SAMPLE_WATER               1           // Skip pre-treatment sample water
     #define SKIP_CONSUMABLE_TESTS           1           // Skip pre-treatment consumable Self-tests
     #define SKIP_DRY_SELF_TESTS             1           // Skip pre-treatment dry self-tests
+    #define RUN_BLOOD_CIRCUIT_PRIME_AGAIN   1           // If this is 1st time priming, run blood circuit prime again
 //    #define SKIP_PRIMING                    1           // Skip Pre-treatment Prime
 //    #define SKIP_WET_SELF_TESTS             1           // Skip Pre-treatment prime wet self-tests
 
Index: firmware/App/Modes/Prime.c
===================================================================
diff -u -r66da0a331c118550341c81098447d9fb8b7237e9 -r9fc107ffe0ed515acf970426ff467abd8e7247a8
--- firmware/App/Modes/Prime.c	(.../Prime.c)	(revision 66da0a331c118550341c81098447d9fb8b7237e9)
+++ firmware/App/Modes/Prime.c	(.../Prime.c)	(revision 9fc107ffe0ed515acf970426ff467abd8e7247a8)
@@ -40,7 +40,7 @@
 
 #define BLOOD_PUMP_FAST_FLOW_RATE_PURGE_AIR_ML_MIN          400                                         ///< Blood pump fast flow rate to fill fluid.
 #define BLOOD_PUMP_SLOW_FLOW_RATE_PURGE_AIR_ML_MIN          150                                         ///< Blood pump slow flow rate after fluid reach lower level of air trap sensor.
-#define BLOOD_PUMP_SALINE_FLOW_RATE_PURGE_AIR_ML_MIN        100                                         ///< Blood pump very slow flow rate during prime saline dialyzer state
+#define BLOOD_PUMP_SALINE_FLOW_RATE_PURGE_AIR_ML_MIN        200                                         ///< Blood pump very slow flow rate during prime saline dialyzer state
 #define BLOOD_PUMP_FLOW_RATE_CIRC_BLOOD_CIRCUIT_ML_MIN      300                                         ///< Blood pump flow rate during prime recirculate blood circuit state.
 
 #define DIALYSATE_PUMP_PRIME_FLOW_RATE_ML_MIN               300                                         ///< Dialysate pump flow rate during priming fluid path.
@@ -263,8 +263,16 @@
     if ( HD_PRIME_WAIT_FOR_USER_START_STATE == currentPrimeState )
     {
         primeStartRequested = TRUE;
-        accepted = TRUE;
         rejReason = REQUEST_REJECT_REASON_NONE;
+
+        if ( TRUE == getReservoirFillStatus( DG_RESERVOIR_1 ) )
+        {
+            accepted = TRUE;
+        }
+        else
+        {
+            rejReason = REQUEST_REJECT_REASON_RESERVOIR_ONE_IS_NOT_READY;
+        }
     }
 
     sendStartPrimeCmdResponse( accepted, rejReason );
@@ -636,6 +644,7 @@
     {
         if ( TRUE == didTimeout( loadcellSteadyVolumeStartTime, MIN_LOAD_CELL_STEADY_VOLUME_TIME ) )
         {
+#ifdef RUN_BLOOD_CIRCUIT_PRIME_AGAIN
             if ( TRUE == runBloodCircuitPrimeAgain )  // TODO: Determine if we still need to go to HD_PRIME_SALINE_SETUP_STATE the first time
             {                                         // since a new state HD_PRIME_SALINE_DIALYZER_STATE has been added
                 runBloodCircuitPrimeAgain = FALSE;
@@ -645,6 +654,9 @@
             {
                 state = HD_PRIME_RESERVOIR_TWO_FILL_COMPLETE_STATE;
             }
+#else
+                state = HD_PRIME_RESERVOIR_TWO_FILL_COMPLETE_STATE;
+#endif
         }
     }
     else